It might sound crazy after this game, but I think I like the Lions' odds to make it to New Orleans better than the Bills.
Lions still have the inside track to the first-round bye, which might be huge with these injuries. If they finish the season 3-0 (and I think they will), their path is probably a Packers or Vikings Divisional Round Game (after going 2-0 against those teams in the regular season), and then either an 8th divisional game on the season, or an Eagles NFCCG. The run defense will absolutely need to figure their **** out by that point (especially against Saquon), but I don't think today makes those any less of winnable games. If anything, as has been said, the injuries are worse than the loss itself if we indeed can't get guys like Alim and CDIII back for that game.
Meanwhile, the Bills are losing sight of any possible first-round bye, and their path will likely look something like Chargers-Steelers/Ravens-Chiefs. The Bills have given up 86 friggin' points in the last two weeks, but have come out of it 1-1, because Josh Allen is playing out of his mind. Now, maybe he can continue that. He's the clear frontrunner for MVP. But it's hard to just expect your offense to score 45 points every week. And with that defense possibly playing Herbert, Lamar, and Mahomes in three consecutive weeks? I could easily see a 45-42 heartbreaking loss in there.
The Lions' defense will bounce back. Since Campbell and Glenn took over, they always have, even in the darkest days.