Boston has a more difficult schedule IMO. Tatum probably sits on the back to back, so either against Atlanta or Charlotte.
Boston has 13 games left. If they maintain their .667 winning% they end up with 8.6 wins, so call it 9. That puts them at 55 wins. Tiebreaker is head-to-head which Detroit owns (2-1). So the Pistons would have to win 6 of their remaining 14 games to match 55 wins and keep the #1 seed.
Let's also remember. Detroit was 0-3 at home in the playoffs last year and 2-1 on the road.